Formalin-fixed Paraffin-embedded, also known as FFPE, is the most popular and widely used method in the medical field in respect of preserving and archiving tissues samples. FFPE has brought a drastic change to the medical field. Firstly, FFPE was introduced in the late 19th century. Needless to say that it is considered the valuable histological method for collecting and preserving the tissues samples and its morphology and cellular details.
According to the study, there are most of FFPE samples out of a billion preserved/achieved tissue samples stored and being studied in a number of tissues banks, laboratories, and hospitals. And therefore it proves on its own that how widely, FFPE method is being used all across the world. The motto of preserved samples is bestowing a wide chunk of information in retrospective molecular studies of diseases tissues.
This highly advanced method of preserving tissue is good at supporting long-term room temperature storage without being degraded. It might sound a bit bizarre but true that FFPE blocks can also be used over decades in order to create additional slides to conduct the microscopic analysis. It needs to be preserved following the correct method so that it can be used over the decades.
Talking about the paraffin block, the embedding tissue actually supports the tissue structure. And it also makes possible to be cut the very thin section from the preserved tissue so that it can be mounted onto microscope slides in order to conduct the further studies. Needless to say that FFPE tissue preservation is regarded as a reliable tool in respect of histological research and analysis: protein harvesting and analysis techniques including MALDI, LC-MS analysis, Western Blotting, and IHC so that valuable molecular weight information on a range of protein species can be churned out. There are a number of FFPE tissues blocks are stored and preserved in respect of historical perspective. And each FFPE Block is preserved adding handwritten or printed labels to the block/cassette associated with patient information.
There is a wide array of TMA advantages making it the best method of preserving tissue sample. Following the TMA method, a total number of 50-500+ cases per slides can be done. Moreover, FFPE tissues can also be stored following more cost-effective and simple methods. It means the budget is not affected to conduct further studies and therefore this method is used by the distinguished medical firm and research-oriented organization and laboratories. This preservation method of sample tissue is also durable as it does not deteriorate quickly in room temperature like Frozen Tissue. FFPE Tissue is also used for multiple uses and can be used in various studies. Needless to say that it brought a great change to the medical field and holds a bright future to take medical science to next level. Conducting research is needed to come up with the best treatment and ways to save people from diseases.
FFPE is not only an inexpensive but also regarded as an easy way to keep tissue samples. To put in simple words, it can be said that it is a bank generally accessed by the experts or medical professionals to conduct further research.